[ Music ]>>I’m a rheumatologist at
HSS and my interest for many, many years has been rheumatoid arthritis, and
in particular, early rheumatoid arthritis, and that’s because I think the
earlier we diagnose it, identify it, and treat it, the better people do. Up until now, we really never looked inside
the joint to determine what cells are there, what subtypes are there, how they’re interacting
with each other, what they’re making. We’ve done a lot of work using some of our
registries and looking retrospectively, and one of the things that have become apparent
was we really needed to look prospectively and gather our own data to
really answer those questions. We set up a consortium across the
United States to do synovial biopsies of actively inflamed joints in rheumatoid
arthritis, and when we did that, we quickly learned that there are basically 4
cellular lineages that are acting in the cells. We want to know how do you translate that
into ways to use the information clinically, and we’re just at the beginning of that. We’re both learning how to
improve clinical outcomes as well as possibly identifying targets
for other therapies. The applications of this sort of collaboration
has been extraordinarily far reaching. I could see in the future that when we have
these biopsies, or even if we take fluid out of the joint, the inflamed fluid, that
there will be standard commercial assays that we use that characterize the type or
subtype of rheumatoid arthritis and therefore, direct a person to use treatment
A, B, C, D, or E. [Music]

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