The bacteria that live inside you shape who
you are on a pretty fundamental level–from your psychology to your body type. But new research also indicates that the billions
and even trillions of tiny creatures in your body play a major role in the way you react
to medical treatments…making your microbial ecosystem a literal matter of life and death. Yeah, hi, it’s me, your favorite microbe
geek here. As we discover more and more about how the
bacteria inside us influence our lives and our health, we also discover more places where
this relationship is really important–and one of these areas is cancer. Yup, it turns out that your body’s bacteria
play a HUGE role in how you respond to cancer and its treatment…and they could hold the
key to the future of how we treat this disease. In the last few decades, one promising way
we’ve started treating cancer is called immunotherapy. It activates the body’s own immune system
to identify and attack cancerous cells. Scientists have been puzzled about why immunotherapy
works so well in some patients, while in others it has little effect. And three recent studies indicate that it’s
likely the patient’s bacterial populations that are the game-changer. Researchers divided patient gut bacteria into
the categories ‘good’ and ‘bad’, and patients with more good bacteria were the
ones who responded well to treatment with immunotherapy–their tumors stopped growing
or even shrank. Researchers then went on to demonstrate in
mouse models that treating cancer patients with a cocktail of the ‘good’ bacteria
improved their response to the immunotherapy. The theory goes that our microbiome is intricately
linked to our immune system. Bad bacteria seem to inhibit our immune system’s
proper functioning, while good bacteria help prep immune cells to be on the lookout for
foreign bodies, like tumors. And we’re still unraveling how all these
relationships work. Immunotherapy is just the beginning. It’s been demonstrated that bacteria can
also be used directly to kill tumors. As in, you can inject bacteria into a tumor
area and watch as they grow to literally suffocate and starve the tumor, because they’re eating
everything the tumor needs to grow. It’s called bacteria mediated tumor therapy,
and it’s surprisingly effective…but perhaps not-so surprisingly, you do then have the
problem of a potentially dangerous bacterial infection that you now need to treat. Balancing that is tricky and has hindered
the progress–and popularity– of this treatment method. 7. Bacteria also tend to produce something called
a biofilm, which is one of my favorite bacterial behaviors. When there’s a certain number of bacteria,
called a quorum, they start to bind together, forming a mass of cells that behaves more
like a single unit than like individual bacteria. Some research shows that biofilm formation
actively disrupts and blocks tumor metastasis, suggesting it could be useful in stopping
the spread of cancer while the patient goes through treatment. And it doesn’t stop there. Bacteria can also be genetically engineered
to detect cancer’s movements–a probiotic form of E. coli, for example, can be taken
by a patient whose subsequent urine output will indicate whether their cancer has metastasized
to their liver–because of the way their body processed that bacteria. As living breathing organisms themselves,
bacteria are constantly producing lots of enzymes and proteins and hormone-like chemicals,
to communicate with each other, to help them eat stuff, to generally just help them live
their little lives. Some bacteria produce toxins that help them
kill whatever wants to eat them, and in some cases, this protein–called a bacteriocin–can
also be toxic to cancer cells. It can be used to aid the effect of certain
cancer drugs, or on its own to tackle tumors in a huge variety of cancers. And even aside from being used directly, bacteria
can be modified to carry targeted cancer treatment to the necessary tissues. But while our invisible, microscopic friends
can help us in the face of this disease, they can actively hinder us, too. A seminal study revealed that in some patients
who didn’t respond well to chemotherapy, bacteria inside their tumors disable those
drugs to protect themselves, meaning the drugs can’t do any damage against the tumor either. This discovery was actually a pretty huge
revelation in our understanding of why some peoples’ systems react to cancer treatment
so differently. And it brings up the question: antibiotics? Or no? Obviously we don’t want bacteria that neutralize
our cancer drugs, but can we get rid of them while also keeping the ‘good’ bacteria
that help our immune system? Not to mention the potential risk of accidentally
creating cancer-drug-killing bacteria that then become antibiotic resistant, which would
be no bueno for anybody. This field is so. exciting. And we’re only just beginning to understand
and take advantage of it. This basically opens up a whole new dimension
in personalized medicine and could give us a much more detailed understanding of the
diseases that plague us, and how to treat them. Special thanks to our sponsor today, Domain.com. Domain dot com is awesome, affordable, reliable,
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online and visit domain dot com. If you think bacteria are as cool as I do
then check out my other video on how your gut microbes are controlling your mind. And fun fact? One of the most prevalent ‘good’ bacteria
that doctors found in patients who responded well to treatment is called Bifidobacterium
longum. Good goin’, little guy. Make sure to keep coming back for all things
microscopically creepy crawly, and thanks for watching Seeker.

100 thoughts on “Scientists Are Using Your Body’s Bacteria To Battle Cancer, Is It Working?”

  1. so how do we turn this miracle 'CURE' into a lifelong treatment so big-pharma bros can get a quarterly return? thats all that matters to the powers that be

  2. Use phage therapy instead of antibiotics for a more specifically targetted effect. Kill the bad bacteria without harming the useful bacteria.

  3. I just noticed all the different hosts use the same exact makeup – foundation, lipstick, glasses, even the males use the same lipstick lololol

  4. can someone put a competent person in charge of hosting these segments ? it feels like I'm listening to a sea otter with brain damage explain science stuff.

  5. Bacteriophages can be used instead of antibiotics to target only specific bacteria right? They also remove possibility of creating more super bugs.

  6. So Yogurt, Kombucha, and other pro-biotics increase gut flora which can increase our odds of successfully battling cancer

  7. I always get the notion that perhaps cancer is not a disease, but instead a new step of human evolution to stop aging. Only problem is that, our bodies don't have the ability to adopt yet.

  8. Cancer cells need glucose to survive as they cannot survive on fat, normal healthy cells can. When you stop eating carbohydrates your body goes into a state of ketosis, you use your body fat reserves, & any cancer cells starve. Fast regularly & you'll never get cancer. Also the THC in cannabis makes cancer cells commit suicide while leaving normal healthy cells unaffected. There are several other virtually cost-free cures that work, but they keep them all top secret because there's no money to be made in selling something that costs nothing, the real money is in prolonging the cancer with treatments that are ridiculously expensive & don't even work. There is no cure for greed.

  9. This video is only interesting if you either wealthy or have health insurance. For those unfortunate few who cant afford health insurance….cancer is terminal.

  10. I lost my friend to cancer last month. I really look forward to this saving someone’s life one day.
    💜 Angela DeCarlo 👼

  11. i have the solution for this, we have the total population of 7.2 billion of humans, so we are on the verge of filling the planet with toxic, deficiency of resources, deadly viruses, etc. so we must use the people who are criminals and useless people for experimentation and by this we can reduce the population and save ourselves from disasters and thrive towards the development of technologies.

  12. Imagine eliminating the risks of bacteria-mediated any therapy by having specially designed phages to attack those bacteria after their job is done.

    Is it possible that one day to have medications based mostly on bacteria and phages and/or other microorganisms?

  13. Bacteria killing cancer but then becoming a potential infection problem reminded me of the Simpsons Bird-eating lizards "we'll release lizard-eating snakes, and when the snakes overrun us well release snake-loving gorillas, and when the gorillas pose a threat we'll just wait for Winter and they'll die out".

  14. I study that..! Alcohol in wine that has antibiotics is a transfer agent two critical organs dormant probiotic that is balanced against that alcohol in the bottle but once you breath the alcohol off threw your lungs now the dormant bacteria becomes living bacteria in that critical organs and where it was carried to,! Why? To heal it.!
    [email protected]

  15. Fun fact: A large chunk of your mass is just the bacteria that inhabit you. For all intents and purposes, they are part of us, just as important as our eukaryotic tissues.

  16. I have cancer and have a deep understanding of how interconnected all living flora and fauna are, it is good to see the science community strengthening this conversation.

  17. Science is greatly benefited by those acknowledging that there might be something else going on here, like gut bacteria, or some other insanely complicated factor we have yet to discover.

  18. My grand mother was an agngellike you, but fox, not fox at all, and you have also the intelectuality to make it more fun, medical beautiful, moraly beautiful, study Cinema 4D for medical, see Mad Microibe Cineversity, morality can be really fun,with no side effects to your heart.

  19. Interesting! So, to know me first get to know my bacterium! 🤔😁.

    BTW, I curiously notice that, while gesticulating you generally keep your right hand fingers close together & those of your left more open 😉. Maybe your right & left bacterias think and act differently!!! 😄

  20. Hello everyone. I recently found out through genetic testing that I have a mutated gene called CHD1 that could cause Hereditary Diffuse Gastric Cancer (70-80% chance in my 30s and I'm 30 now). We believe my grandmother died of this in her late 20s.

    The national recommendation is to remove the stomach, Total Gastrectomy. The diffuse cancer is very difficult to detect in the liner of the stomach so biannual biopsies via endoscopy are recommended if opting pass on the gastrectomy.

    I do not want to live without a stomach, therefore I've decided on routine biopsies. At the first sign of cancerous cells (still a very difficult discover with biopsies) I will obviously have to give in to the Gastrectomy.

    My hopes are that I might find an alternative solution, which is why I'm asking all around for advice and guidance.

    Your opinion and guidance means a lot. Any thoughts? Thanks

  21. aajonus vanderpanitz WAS eating bacteria over 30year in his diet never had even a vomit as he once said himself 😂

  22. Hey! I’m going to talk about a particular situation.

    Can this living organisms behave in a way that they build this films to regulate respiration. I mean, can they grow inside our “caverns” to block air flow with the intention to balance someones health?

    I can explain in further detail if needed.

    Please reply.

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